Two other mutants, ms*6064 and ems63131, exhibit highly irregular anther differentiation.
Nevertheless, as observed in other murine knockout models of molecules important for cartilage development, it could be possible that abnormalities arise only in the embryo during chondrogenesis and are compensated later in development via redundancy or irregular cellular differentiation and proliferation.
In G2 lesions, the cell arrangements were irregular, with mild differentiation and minimal nuclei atypia.
Furthermore, T-cells were shown to exhibit irregular modes of differentiation and cytokine expression upon stimulation with S. aureus [ 16, 17], and S. aureus specificity was found in T-cell clones generated from peripheral blood lymphocytes of GPA-patients [ 17].
Spherical bioactive glasses (SBGs) exhibited higher osteogenesis and odontogenic differentiation than irregular BGs.
In LIF− conditions for 5 days, the mESC colonies on 8 kPa substrates, similar to those on 3.5 kPa substrates, became much more spread and irregular, showing signs of differentiation (Fig. 4A), and significantly elevated their tractions and stiffness (Fig. 4C E), accompanied by diminishing Oct3/4 expression (Fig. 4B).
It has been proposed that PE involves irregular CT to SCT differentiation.
In 14q11.2, a common copy number variable region, copy number differentiation may produce irregular isoforms of olfactory receptors, and then causes mis-perception in the olfactory and neuronal cells.
Sabri et al. found increased numbers of MKs in the bone marrow that produced irregular proplatelets, indicating a premature differentiation of MK precursors (Sabri et al., 2006).
