Sentence examples for excessive differentiation from inspiring English sources
We previously reported that dC1GalT1 synthesizes T antigen expressed in hemocytes, lymph glands, and the central nervous system (CNS) and that dC1GalT1 mutant larvae display decreased numbers of circulating hemocytes and excessive differentiation of hematopoietic stem cells in lymph glands.
The upregulation of Ngn3 is associated with precocious and excessive differentiation [7].
These embryos, with just one copy of Dll1, show also a full rescue of the excessive differentiation of Chx10+ V2a (Fig. 6 B,K), and of Evx1+ V0 INs (Fig. 6 E,H,L), confirming the functional activity of the Dll1 allele.
Disrupting this balance can lead to excessive differentiation and stem cell exhaustion, hypoplasia or squamous metaplasia.
For examples, G-CSF administration after cytotoxic agents that damage bone marrow stem cells exacerbates long-term stem cell damage through excessive differentiation stimulation [5].
These phenotypes have been attributed to excessive differentiation of neural progenitor cells (NPCs) into neurons, which depletes the progenitor pool in notch pathway mutants.
Excessive differentiation-associated proliferation leads to depletion of stem cells and degeneration of tissue with age.
This phenotype is apparently associated with excessive differentiation-proliferation of SSCs, which disturbs the long-term maintenance of stem cell pool, thereby leading to the exhaustion of spermatogenesis with age.
Possibly, the loss of Pten might disturb the balance of self-renewal and differentiation and promote excessive differentiation-associated proliferation of SSCs, thereby giving rise to enlarged testes in young mice but causing the depletion of stem cell source and infertility with age.
b During airway formation, mesodermal (mesenchymal) RA signaling restricts SM gene expression (Acta2, Myh11, Tagln) in distal lung, preventing ectopic and excessive SM differentiation while airways are branching.
Moreover, ARQ 087 inhibited activity of FGFR1 and FGFR2 mutants associated with Pfeiffer, Apert and Beare-Stevenson craniosynostoses, and rescued FGFR-driven excessive osteogenic differentiation in mouse mesenchymal micromass cultures or in ex vivo calvarial organ cultures.
