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In summary, we provide a tool for the measurement of synergy strength for combination perturbation experiments that might help define pathway topologies and direct clinical trials.
As β-catenin staining had not been carried out on this cohort we used AXIN2 expression to define pathway activation.
It employs the widely used SAM software package to define "pathway signatures" from known molecular perturbations [ 4].
While 5 of the 13 genes in this cluster define pathway enrichment, 7 factors are yet missing functional annotation and it will be interesting to consolidate their likely involvement in male gametocyte maturation in future studies.
This allowed us to define pathway-specific outliers based on the theoretical chi-squared 97.5th percentile, which corresponds to a p-value
We used pharmacometabolomics to define pathways implicated in variation of response to treatment.
The Diana miRpath application [ 32] was used to define pathways enriched in the predicted targets for CC significant miRNAs.
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