Sentence examples for define pathway from inspiring English sources

In summary, we provide a tool for the measurement of synergy strength for combination perturbation experiments that might help define pathway topologies and direct clinical trials.

As β-catenin staining had not been carried out on this cohort we used AXIN2 expression to define pathway activation.

It employs the widely used SAM software package to define "pathway signatures" from known molecular perturbations [ 4].

While 5 of the 13 genes in this cluster define pathway enrichment, 7 factors are yet missing functional annotation and it will be interesting to consolidate their likely involvement in male gametocyte maturation in future studies.

We validated our findings from this cohort using array data generated from a subset of our IHC cohort, for which we could define pathway status using β-catenin IHC.

Overall, these results suggest that the loss of DRB2 does not influence the general output of the RdDM pathway (i.e. DNA methylation of targets), at least in standard plant growth conditions, and that the increase in p4-siRNA observed in drb2 plants is probably the result of a crosstalk with another yet to define pathway.

This allowed us to define pathway-specific outliers based on the theoretical chi-squared 97.5th percentile, which corresponds to a p-value < 0.025 for a one-sided test [ 30].

We used pharmacometabolomics to define pathways implicated in variation of response to treatment.

The Diana miRpath application [ 32] was used to define pathways enriched in the predicted targets for CC significant miRNAs.

Further studies on mechanisms underlying reduced kidney pericyte number in aging are needed to define pathways that lead to fibrosis.

In this study we define pathways by which UvrD, RuvABC, and RecBCD allow cells to resist TLD.