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First, genetic studies of sex determination in laboratory mice have shown that the sex determining pathway is sensitive to genetic background [ 48- 51].
Expression of Sry activates Sox9 and the male determining pathway leading to Dmrt1 (Koopman 2005).
Another repository, hiPathDB, only lists all of the pathways that contain at least one of the input genes with no means for determining pathway overlap.
A number of techniques and tools have recently emerged, aimed at determining pathway activities based on topological information of pathways and gene expression/protein activity levels.
Finally, we plan to enhance and expand our methods for determining pathway signatures by expanding the scope of arrays on which we base a given profile, looking across all of GEO for relevant studies.
We first inferred selection on Sxl associated with its recruitment to the sex determining pathway of Drosophila by analyzing an alignment of Sxl sequences from the Drosophila species, the Tephritidae and M. domestica.
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Nichole's lab's research will be aimed at understanding the neural mechanisms of decision making in human aging and determining pathways to good decision making across the lifespan.
In the ovary, the β-catenin dependant canonical pathway of WNT4 leads to ovarian determining pathways.
The GDAS data is considered suitable for determining pathways of dispersal over long distances.
Overweight and obesity is a problem in children in particular and determining pathways of transmission is important in prevention.
Using a novel gene clustering strategy we determined pathway relationships from a genome-wide transcriptional dataset of skeletal myoblast differentiation.
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