An improved understanding of how signaling pathways interact is therefore warranted, as it may facilitate tailored therapy approaches based on identified pathway abnormalities.
Thus, each integer value of S marks a reference structure of TDG along the identified pathway, while the divergence, Z, can vary between zero Å2, for no divergence, to an unlimited value.
Solid arrows indicate the identified pathway.
In future studies, it will be important to determine how critical this newly identified pathway is for lung tumorigenesis.
Ingested residues of lead ammunition are a recently identified pathway of lead exposure to human consumers of gun-killed game animals.
Interestingly, the majority of identified pathway maps for both gene expression and proteomics sets are related to metabolic processes, most of them to fatty acid metabolism (Table S3).
Again, as with the common genes described above, even within one identified pathway, the profiles of changes in each time course were frequently quite different.
In this case, the multiple functions contained in one identified pathway may suggest that its collaborator pathway participates in more than one cellular function.
In order to investigate the characteristics of the identified pathway structure, we next carried out a steady-state analysis for ERK and B-Raf responses under the constant inputs of Ras- and Rap1-GTPs (Figures 5B and 5C).
Thus, at the cost of reducing the accuracy of one of the two pathways in each identified pathway pair, it was still possible to gain much insight of the gene functions using synthetic lethal interaction data alone.
The Hpo pathway has been shown to play critical roles in the regulation of cell proliferation, apoptosis, and growth, but little is known of the effects of this newly identified pathway on the process of cell differentiation.
