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After nucleolin-mediated efficient binding and cellular uptake of GQDs/PPIX assemblies, the strong red fluorescence of GQDs/PPIX complex provides a powerful tool for biological imaging.
Results with human cervical cancer cells (HeLa), which have been shown to exhibit high folate receptor (FR) expression, confirmed FTML surface binding and cellular uptake.
In the present contribution, we supplement these findings by showing that no significant difference in competition binding and cellular uptake and internalization exists between Ga3+ and Lu3+ chelated CP04.
The results showed that iRGD peptides could facilitate the binding and cellular uptake of drug-loaded cMLVs and consequently enhance the antitumor efficacy in breast tumor cells, including multidrug-resistant cells.
Thus, this 9-amino acid region holds a prominent position on the capsid and includes sites shown in some serotypes (notably AAV2) to be critical for heparan sulfate binding and cellular uptake (Kern et al, 2003; Opie et al, 2003).
Binding and cellular uptake of particles were determined by measuring doxorubicin fluorescence using flow cytometry.
Similar(54)
Antagomirs sequences can be modified in order to improve their stability, binding efficacy, and cellular uptake.
Normally, nucleic acids are quickly degraded in biological compartments; thus various chemical modifications have been tested to stabilize their structure and to increase binding efficacy and cellular uptake.
Increasing the surface area of the polypyridyl ligand generally results in a significant increase in the intercalative binding strength and cellular uptake.
Therefore, the correct balance between albumin-binding affinity and cellular uptake efficiency could provide a rationale for the in vivo results of IC7-1-Bu.
Nanoparticles binding to the plasma membrane and cellular uptake are probably a necessary condition for its exertion of cytotoxicity.
Related(15)
binding and cellular activation
binding and intracellular uptake
binding and endocytotic uptake
binding and cellular component
binding and cellular compartment
binding and subsequent uptake
binding and cellular association
binding and selective uptake
binding and cellular localization
binding and cellular binding
binding and cellular import
binding and cellular differentiation
binding and cellular reporter
binding and active uptake
binding and cellular entry
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