MT1 also lost hundreds of genes whose functions fell within transcription, translation, DNA and RNA binding, and cellular component synthesis.
The other 40%% of the genes were mainly involved in ion transport, regulation of transcription and translation, DNA and RNA binding and cellular component synthesis, such as membrane components, organelle organization and cellular protein components (Fig. 2d).
Of the terms extracted, terms falling in the molecular function (binding) and cellular component (membrane, nucleus, chromosome and intracellular) ontologies were not included in the analysis, as we considered these terms non-specific with regard to FAS and non-specific in general.
Gene ontology enrichment analysis on molecular function showed significant enrichment in cell adhesion, protein binding, and transport activities, and cellular component clustering identified significant enrichment of ribosomal subunits (Additional file 3).
For ORFs containing trinucleotide repeats, however, terms within the Molecular Function domain (nucleic acid/DNA binding and transcription factor/regulator activity) and Cellular Component domain (nucleoplasm) were significantly enriched.
"Oxidation reduction" (102) was the most dominant biological process term, while the most dominant molecular function and cellular component terms were "protein binding" and "cytoplasma", respectively.
The most abundant GO slims within the biological process, molecular function, and cellular component categories were cellular process, binding, and membrane, respectively.
The most abundant GO slim terms were Transport, Nucleotide binding, Plastid, in terms of Biological process, Molecular function and Cellular component, respectively.
In the molecular function and cellular component categories, several terms such as 'DNA binding' and 'nucleus', which are related to transcription factors, were enriched (P < 0.001).
Cellular process, binding and membrane are the most abundant GO slims within the biological process, molecular function, and cellular component categories, respectively.
Biosynthetic process, ion binding and cytoplasm were the most abundant GO terms within the biological process, molecular function, and cellular component categories, respectively.
