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Functional analysis of these coregulated clusters can be found in Tables 2 and 3. Analysis of gene ontogeny (GO) terms in coregulated clusters indicated diverse classes of biological functions of regulated genes, including several effects on protein metabolism, ion binding and cellular differentiation (Table 2).
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Sonic Hedgehog (Shh) is a secreted morphogen that directs patterning and cellular differentiation through binding to its receptor Patched (Ptc).
They typically heterodimerize with the retinoic X receptor (RXR) and regulate expression of genes involved in development, metabolism, and cellular differentiation after binding to their respective response elements (PPREs) [ 27].
Well documented functions for non-coding RNA include regulation of the genome (through chromatin modification, DNA binding, and protein binding) and of cellular differentiation during development [ 39– 41].
DGF with deep sequencing has been implemented to uncover cell-specific TF binding motifs in humans, yielding expansive knowledge on regulatory circuits and the role of TF binding in relation to chromatin structure, gene expression, and cellular differentiation [ 19, 78].
In addition to its cdk-binding function, D-type cyclins have additional cdk-independent properties in cellular growth, metabolism and cellular differentiation (Fu et al, 2004).
To investigate the potential direct SRY binding to the Tcf21 promoter in vivo a ChIP assay with chromatin samples from embryonic testis undergoing sex determination and cellular differentiation was performed.
Kretz, M. TINCR, staufen1, and cellular differentiation.
Nuclear cloning, epigenetic reprogramming, and cellular differentiation.
Streuli, C. Extracellular matrix remodelling and cellular differentiation.
Its expression was shown to undergo changes during embryonic development and cellular differentiation as well7.
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