In time-course adhesion experiments, bacterial binding was higher for IFN-γ-treated cells at early time points after infection, and cellular association appeared to reach a plateau after 2 h in the case of piliated bacteria (#18.18) (Fig. 6C).
Cardo, L., Sadovnikova, V., Phongtongpasuk, S. , Hodges N. J. & Hannon, M. J. Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity.
As can been seen from Fig. 7, preincubation with cRGD protected the cells against PDT, likely by blocking the binding by competitive inhibition of the construct with integrins and thus preventing receptor binding and cellular uptake.
We identify critical regions within these molecules that require ribose nucleotides and show a direct correlation between binding affinity/stability and cellular activity.
Surface plasmon resonance studies clearly indicate that this increase in cellular association is due to a decrease in the iron release rate and not to differences in binding affinity of the mutants to the Tf receptor (TfR).
Testing SiO2, TiO2 and polystyrene particles with varying surface carboxylation, together with protein and polyethylene glycol surface coatings, we find that cellular associations and protein binding both strongly depend on particle surface chemistry.
Self-diffusion rates are quite sensitive to structural changes and to binding and association phenomena.
Wu RA, Tam J, Collins K. DNA-binding determinants and cellular thresholds for human telomerase repeat addition processivity.
Through our combination of assays a clear correlation between target-binding affinity and cellular activity was found (results from all assays collated in Supplementary Table 1).
The genes encoding cellular retinol-binding protein-1 (Rbp1) and cellular retinoic acid-binding protein-2 (Crabp2) were elevated 8.6- and 6.2-fold, respectively, consistent with transactivation of RAR.
