Sentence examples for based on mutational analysis from inspiring English sources

For instance, FGFR1 Y-766 (SNQEpYLDLSMP) is reported to bind to PLCγ1 in a pTyr dependant manner based on mutational analysis of FGFR1 [ 55, 56].

NF2 is recognized as a putative tumor suppressor gene in spinal ependymomas based on mutational analysis and increased incidence of ependymoma in patients with NF2 familial syndrome.

Evidence based on mutational analysis predicts that pancreatic cancers are confined to the pancreas for many years, perhaps a decade or more before spreading beyond the pancreas.

However, the significance of ParA DNA-binding activity remains unclear, even though this activity is essential for the segregation process based on mutational analysis (Hester and Lutkenhaus, 2007; Castaing et al., 2008; Ptacin et al., 2010; Schofield et al., 2010).

The set of human cancer genes was selected from the literature based on mutational analysis and/or roles in processes such as chromosomal stability, promoter methylation or control of mitotic checkpoints [ 3, 4, 7, 24- 28].

Based on mutational and structural analysis of Ras-like GTPases, it seemed likely that mRap1A-retro1 and mRap1A-retro2 would encode for activated (GTP-bound) versions of Rap1A.

Putative functional effects of mutations are based on mutational patterns.

Hierarchical analysis revealed that the cell lines segregated on the basis of EGFR mutational status (mutant versus wild-type), and expression signatures were identified by supervised analysis that distinguished the cell lines based on mutational status (wild-type versus mutant) and type of mutation (L858R versus Δ746-750 Δ746-750

Hierarchical analysis revealed clustering of the cell lines based on mutational status; the EGFR-mutant cells lines clearly segregated from the -wild-type cell lines (Fig. 1).

Patients were then stratified in three equally large groups based on mutational burden.

PDAC can be classified based on mutational subtypes and 18gene alterations.