Sentence examples for based on mutational status from inspiring English sources

Hierarchical analysis revealed that the cell lines segregated on the basis of EGFR mutational status (mutant versus wild-type), and expression signatures were identified by supervised analysis that distinguished the cell lines based on mutational status (wild-type versus mutant) and type of mutation (L858R versus Δ746-750 Δ746-750

Additionally, we compared our genomic predictor (gene signatures and DLDA) to predictions based on mutational status alone, assuming sensitivity in the presence of exon 19 or 21 mutations, or resistance in the absence of EGFR mutations, or presence of an exon 20 mutation.

Hierarchical analysis revealed clustering of the cell lines based on mutational status; the EGFR-mutant cells lines clearly segregated from the -wild-type cell lines (Fig. 1).

Furthermore, when compared to predictions based on mutational status alone, the genomic predictors (50- and 180-gene models) perform better in determining a priori sensitivity (Table 3).

Putative functional effects of mutations are based on mutational patterns.

Patients were then stratified in three equally large groups based on mutational burden.

Davies, H. R. et al. HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.

PDAC can be classified based on mutational subtypes and 18gene alterations.

These studies suggested several hypotheses based on mutational biases or selective constraints.

No differences in the involvement of oncogenic pathways were noted between the two sites, based on mutational profiles.

To date, the characterization of AML based on the mutational status of the FLT3 gene has shown not to be very informative in predicting the activity of any of these FLT3 receptor inhibitors and their effects on signaling transduction remains unknown.