No differences in the involvement of oncogenic pathways were noted between the two sites, based on mutational profiles.
Putative functional effects of mutations are based on mutational patterns.
PDAC can be classified based on mutational subtypes and 18gene alterations.
Unbiased clustering, based on mutational context, revealed clinically relevant subgroups regardless of the tumors' tissue of origin, highlighting similarities in evolutionary dynamics leading to hypermutation.
Hierarchical analysis revealed clustering of the cell lines based on mutational status; the EGFR-mutant cells lines clearly segregated from the -wild-type cell lines (Fig. 1).
These studies suggested several hypotheses based on mutational biases or selective constraints.
31 Based on the mutational profile, it is highly likely that G17V RHOA mutation-positive AITL and G17V RHOA mutation-positive PTCL-NOS harboring features of AITL constitute a single disease entity.
Chemoprevention due to gerosuppression does not depend on mutational profile of cancer cells or on any features of cancer cells.
It is not discrimination based on racial profiling.
Species identification was based on biochemical profiling.
