Sentence examples for based on mutational context from inspiring English sources

Unbiased clustering, based on mutational context, revealed clinically relevant subgroups regardless of the tumors' tissue of origin, highlighting similarities in evolutionary dynamics leading to hypermutation.

Putative functional effects of mutations are based on mutational patterns.

PDAC can be classified based on mutational subtypes and 18gene alterations.

Here, we review data that show substantial genetic similarities across major anatomic cancer types and that propose novel tumor classifications based on mutational profiling.

Hierarchical analysis revealed clustering of the cell lines based on mutational status; the EGFR-mutant cells lines clearly segregated from the -wild-type cell lines (Fig. 1).

These studies suggested several hypotheses based on mutational biases or selective constraints.

No differences in the involvement of oncogenic pathways were noted between the two sites, based on mutational profiles.

Furthermore, when compared to predictions based on mutational status alone, the genomic predictors (50- and 180-gene models) perform better in determining a priori sensitivity (Table 3).

For instance, FGFR1 Y-766 (SNQEpYLDLSMP) is reported to bind to PLCγ1 in a pTyr dependant manner based on mutational analysis of FGFR1 [ 55, 56].

These observations indicate that some SNPs in dbSNP are truly phenotypically mutational, and the interpretation of their functional consequences should be based on the context of carriers in the general population (or specific populations in case of founder mutations), or in the context of the phenotypic impact of the mutant molecule (for example, drug metabolism).

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