Putative functional effects of mutations are based on mutational patterns.
Patients were then stratified in three equally large groups based on mutational burden.
PDAC can be classified based on mutational subtypes and 18gene alterations.
Davies, H. R. et al. HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.
Unbiased clustering, based on mutational context, revealed clinically relevant subgroups regardless of the tumors' tissue of origin, highlighting similarities in evolutionary dynamics leading to hypermutation.
Here, we review data that show substantial genetic similarities across major anatomic cancer types and that propose novel tumor classifications based on mutational profiling.
Hierarchical analysis revealed clustering of the cell lines based on mutational status; the EGFR-mutant cells lines clearly segregated from the -wild-type cell lines (Fig. 1).
These studies suggested several hypotheses based on mutational biases or selective constraints.
No differences in the involvement of oncogenic pathways were noted between the two sites, based on mutational profiles.
Furthermore, when compared to predictions based on mutational status alone, the genomic predictors (50- and 180-gene models) perform better in determining a priori sensitivity (Table 3).
