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Exact(21)
CFX suffers from moderate oral bioavailability [23], as it chelates with calcium-, magnesium- and aluminium-containing salts upon concomitant administration [24].
In another study on morphine sulfate formulated as EMBEDA extended release capsules (60 mg), bioavailability upon concomitant ingestion of alcohol in healthy subjects was examined under fasted conditions in an open-label, randomized, single-dose, 4-way crossover, 4-sequence drug interaction study.
Upon concomitant release of primary and tertiary granules, NE can potentiate MMP9 through direct activatory cleavage and/or indirect degradative cleavage of its inhibitor tissue inhibitor of metalloprotease-1 (TIMP-1), leading to increased collagen degradation, tissue damage, and bronchiectasis in CF children [67, 68].
The sequential statistical analysis based on experimental design coupled with least squares multiple regression has been made to analyze the dependence of respiratory and photosynthetic responses upon concomitant modulation of light intensity as well as acetate, CO2, nitrate, and ammonia concentrations in the culture of C. reinhardtii [114].
Strong, significant TGF-β expression was also observed in the aspirates after 21 days especially when rAAV-hTGF-β was provided to the aspirates as noted by immunohistochemical analysis that revealed the strongest signal upon concomitant TGF-β and sox9 gene transfer at the highest vector doses applied (20 μl each vector) relative to rAAV-lacZ and to untreated aspirates (Fig. 1a).
The noncanonical nature of the cognate response elements present in the promoter enabled strong responsiveness only upon concomitant activation of both transcription factors.
Similar(39)
While eDNA was detected in growing planktonic aggregates (Figure 2) and in surface attached biofilms (Figure 4), the results suggested that massive amounts of eDNA were released upon starvation concomitant to a drastic increase in dead cells (Figure 4).
A person with PA may have widely variable measures in GFR depending upon age, concomitant medication use and duration of aldosteronism, all of which can influence a single measure of GFR without reference to the laterality status.
In the present work, DOE coupled to standard least squares multiple regression have been used to model the dependence of different respiratory (CR, MACYT, MAALT) and photosynthetic (P800, ΦPSII800, NPQ800) responses upon the concomitant modulation of light, carbon and inorganic nitrogen sources in the culture medium of C. reinhardtii.
In the present work, DOE coupled to standard least squares multiple regression have been used to model the dependence of several respiratory and photosynthetic responses upon the concomitant modulation of light intensity and acetate, CO2, nitrate and ammonium concentrations in the culture medium of C. reinhardtii.
We propose that the mechanism for the phenomenon is increased RXR heterodimerisation and DNA binding upon ligand binding concomitant with transcriptional co-repressor binding.
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