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In principle, TCRs relay information to intracellular signaling motifs of the associated CD3 subunits, while CD4 recruits the kinase Lck to those motifs upon coincident detection of pMHCII.
Our data show that LTD triggered by LC activation depends critically upon coincident (test pulse) stimulation of afferent fibers to the CA1 region and is consistent with other reports as to the necessity of coincident information signals for the induction of synaptic plasticity.
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Presumably, learning of this type depends upon the coincident arrival in the cerebellar cortex of a conditioning stimulus (via mossy fibres) and an unconditioned stimulus, or teaching signal, via climbing fibres from the inferior olive (Hong and Optican, 2008).
The model, though not intrinsically contextual, acquires this quality upon post-selection of coincident detections.
Moreover, we expanded upon the description of the coincident periocular disease that occurred in arthritic SKG mice, which indicates the involvement of self-reactive T cells in the eyelid and/or conjunctival inflammation.
Second, our data indicate that ductal ectasia in Hhex-deficient mice occurs only after birth, and thus is coincident with exocrine activation upon feeding.
Thus, the primary characteristics of root growth that are affected upon inhibition of exocyst function are coincident with those root growth characteristics that are adjusted in response to environmental stress.
PET radiotracers are small molecules containing a single positron emitting isotope (e.g., C, half-life of 20.38 min, or F, half-life of 109.8 min) and are detected in vivo by the measurement of highly tissue-penetrant and coincident γ rays produced upon positron annihilation.
As you can see, we observed coincident and rapid mCerulean quenching upon addition of nitrate (Aphrodite, when excited directly is unaffected like in the fluorimeter assays).
H2Bub1 levels are highest in interphase, when RNF20 is spatially constrained within the nucleus, and are rapidly lost upon entry into mitosis in a manner coincident with RNF20 becoming spatially redistributed away from the chromosomes and into the cytoplasm.
To that end, it seems that cryptic variation in the mutation rate is not dependent upon specific local context effects that are associated with coincident SNPs and that the general excess of coincident SNPs is not driven by local context effects; indeed, no single context can explain more than a very small fraction of coincident SNPs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com