While aspects of these properties and processes can be studied in vitro, their full complexity can only be understood in a viable tissue context.
The impact of cell and tissue context, assay type, steroid metabolism and hormonal milieu in determining progestin-mediated activity are also presented.
The two ERbeta genes in zebrafish have different levels of expression depending on tissue context.
Wnt5a has been reported to activate both canonical and noncanonical signaling depending on receptor, cellular and tissue context [3] [5].
In addition, hrs and stam contribute to either enhance or attenuate EGFR signalling activity, depending on the tissue context.
Terms like "niche" borrowed from ecology are more and more used to describe the impact of tissue context and microenvironment on cell differentiation in vivo [22].
Thus, whether or not MYC and K-rasG12D functionally cooperate to activate critical tumor promoting pathways appears to depend upon the specific tissue context.
To study the hepcidin expression in the whole tissue context, we examined tissue samples from patients with and without acute cholecystitis.
The canonical effector of GHSR is phospholipase C dependent [4], [6], but GHSR activation by ghrelin can elicit the activation of other pathways depending on the tissue context [37].
Our study expands upon their work by adding the details of the soft tissue context, investigating the comparative anatomy of this system across the breadth of the Odontoceti, and applying vibrational analysis.
Capable of rapid dynamism and motility, they also synthesize and release multiple cytokines, chemokines, neurotrophic factors, and neurotransmitters that allow them to interact with multiple CNS cell types and exert cytotoxic or cytoprotective effects depending on the tissue context [23].
