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Our studies have pioneered the efficacy of mitochondrial transplantation using direct tissue injection [19, 20].
In conclusion, our results point to autologous and micro-fragmented adipose tissue injection as an innovative and safe approach for the treatment of diffuse degenerative knee chondropathy.
Despite the lack of a control group and the association with different surgical procedures, the very positive outcome seems to point to micro-fragmented adipose tissue injection as a feasible concomitant procedure in the treatment of degenerative knee chondropathy.
Fig. 2 Box plot of VAS pain, Tegner Lysholm knee, IKDC subjective and total KOOS pre-operatively (t0) and at 12 months (t12) after micro-fragmented adipose tissue injection.
Results are expressed as median and interquartile range Fig. 3 Box plot of the five KOOS subscale scores pre-operatively (t0) and at 12 months (t12) after micro-fragmented adipose tissue injection.
Up to date, multiple formulations of SFNs with different encapsulation methods and drugs have been described but it is still unknown their biodistribution in vivo after intravenous administration or tissue injection.
Similar(46)
It might be like taking 10 deep tissue injections at once.
Its main limitation is that it required direct soft tissue injections via a lateral incision and an anteromedial arthrotomy, which can modify the normal anatomy.
Joint, spinal and soft tissue injections are commonly performed by rheumatologists in their daily practice.
However, in our study, all physicians were rheumatologists, with a mean experience in joint and soft tissue injections of 22 years.
26 27 28 Studies comparing epidural steroid injections with epidural saline or local anaesthetic injections have shown less benefit from steroids 26 29 30 than those comparing epidural steroid injections with sham or soft tissue injections.
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