Once in captivity, diseased foxes had good appetite and generally survived with no substantial disease progression or death, but they showed no evidence of natural recovery.
Baseline measures indicate substantial disease burden and healthcare resource utilisation.
However, there remains a substantial disease burden from chronic heart failure.
Chronic migraine has an estimated worldwide prevalence of 1.4% to 2.2% [5], and is associated with substantial disease burden.
Dengue is the most common arboviral infection of humans, responsible for a substantial disease burden across the tropics.
Baseline quality of life measures indicate substantial disease burden, as measured by mean (SD) MSQ (56.2 [12.4]), EQ-5D index (0.47 [0.38]), and EQ-5D VAS scores (47.7 [25.1]).
Consistent with previous research [10, 41, 7], the majority of patients (~80%) in the current study are female, with a mean age of ~45 years, substantial disease burden (as measured by the MSQ), and most have previously used beta-blockers, antidepressants, or antiepileptics for treatment of CM.
Respiratory viruses have been associated with substantial disease burden in relation to hospitalization and mortality.
Severe obesity is correlated with a substantial disease burden in reproductive health.
The season 2003 04 was notable for the fact that population morbidity rates in young children aged 0 4 were more than twice those of the overall all-age morbidity, indicating substantial disease burden in the young.
However, they have not caused substantial disease in these regions.
