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Phenodiv and phenosim categories had comparable proportions of essential disease genes.
Here we perform a comparative study on the features of human essential, disease, and other genes.
The majority of essential, disease related, tumour suppressor, oncogenic and approved drug target proteins were found to be centrally located.
As shared genes show higher centrality we speculated that these might be enriched with essential disease genes compared to specific genes.
Shared genes showed an enrichment of essential disease genes compared to specific (44% to 17%; Fisher's Exact P < 0.001; Figure 6).
Instead of dividing the human genome into disease vs. non-disease genes, we choose a three-way classification, namely, UEHGs (presumed "essential"), disease, and other genes.
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Identification of essential disease-specific knowledge and clinical skills required by community-based physiotherapists to support a rheumatology service [ 54, 55].
Goh et al. [ 8] found that non-essential disease genes tend to be tissue specific located at the functional periphery of the interactome and do not necessarily encode hubs.
This passive immunity is essential for disease resistance before piglets develop their own immunity, so all newborn piglets need to nurse immediately.
Timely diagnosis and management is essential for disease control.
Finding a highly effective drug delivery carrier with low cytotoxicity is essential for disease therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com