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'underlying disease' is correct and usable in written English.
You can use it to refer to a medical condition or illness that a person has that has not been diagnosed or is not the primary focus, but which may be causing other symptoms. For example, "The patient's chronic fatigue may be caused by an underlying disease."
Exact(59)
Univariate statistical comparison of those age < 65 with no underlying disease versus age < 65 with underlying disease.
Age and underlying disease were strongly correlated: all our patients with severe underlying disease were older (age >65 years).
Particulates in the air pollution are thought to cause inflammation that exacerbate underlying disease.
Treatment is directed at eliminating the underlying disease.
Computed tomography (CT) is usually requested to detect underlying disease.
Differences may also relate to the underlying disease state.
Molecular mechanisms underlying disease suppression will be addressed, if appropriate.
Underlying disease and proper sizing of prostheses are two challenges that lead to component failure.
Lactate concentration may be high, but not due to citrate accumulation but to underlying disease.
Raynaud's occurs most commonly without an underlying disease.
Similar(1)
The precise mechanisms underlying disease-associated DNM2 mutations are unresolved.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com