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TD-5471 is structurally differentiated from milveterol and its long duration of action is consistent with a correlation with hydrophobicity observed in other long-acting β2-agonist discovery programs.
A series of substituted benzylamines 2 48 were prepared as part of a strategy to identify structurally differentiated and synthetically more accessible selective serotonin reuptake inhibitors, relative to clinical candidate 1.
The extent of differentiation was assessed by combining the more differentiated components (papillary and follicular) together, and comparing these with the less structurally differentiated components (solid and trabecular) combined.
However, we have shown in an unpublished study that tumours with a solid morphology have a significantly higher proportion of cells in cycle than tumours with a more structurally differentiated phenotype (Verykoglou et al, 2004).
However, their differing genetic potentials for biosynthesis of cofactors and amino acid precursors may allow the coexisting AMD plasmas to take advantage of microniches that occur in structurally differentiated biofilms [ 87].
Similar(54)
We refer to the solid and trabecular components as structurally less differentiated, but would emphasise that these are part of a papillary carcinoma spectrum and are completely different from the undifferentiated (anaplastic) carcinomas of the thyroid, which lack any trace of structural or functional thyroid differentiation.
Purified methylenedianiline (MDA) regioisomers were structurally characterized and differentiated using tandem mass spectrometry (MS/MS), ion mobility-mass spectrometry (IM-MS), and IM-MS/MS in conjunction with computational methods.
The male gametes of certain mammals may represent an ideal model for testing the connections between different kinds of modularity, as they are highly polarized cells with structurally and functionally differentiated regions that are morphologically recognizable [ 7].
Voreloxin is differentiated both structurally and mechanistically from other topoisomerase II poisons currently in use as chemotherapeutics.
C3G is a 140 kDa protein, build up with several modular domains clearly differentiated, both structurally and functionally.
If something starts simply, as life did, there is an inevitable tendency towards complexification and differentiation (true in astronomy and geology too; even the earth's inorganic crust has become more differentiated and structurally complex over time); but complexification will not be evenly spread across the tree, but can go into reverse locally.
Related(20)
automatically differentiated
structurally heterogeneous
structurally diverse
structurally sensitive
structurally distinctive
systematically differentiated
structurally privileged
structurally distinct
structurally various
structurally segregated
structurally divergent
structurally differing
structurally distinguished
structurally discrete
structurally disparate
structurally complex
structurally bizarre
structurally daring
structurally flawed
structurally impossible
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