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We considered a nucleotide site as structurally sensitive if the structural sensitivity was larger than 0.1.
The null hypothesis in this analysis assumes that the conservation status of 4-fold degenerate sites (e.g. conserved or non-conserved) is independent of the corresponding structural status (e.g. structurally sensitive or non-sensitive) in any given stratum.
We define structurally sensitive sites as those with putative local structure-disruptive mutations.
We define structurally sensitive sites in mRNA as those with putative local structure-disruptive mutations.
Naturally, the outline also includes a number of anti-terrorism regulations, including the implementation of cameras and sensors at "structurally sensitive points" around bridges and tunnels.
The results of the evaluations show that the tuffs are structurally sensitive to fractures due to tectonic setting of the region.
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It has been fairly well observed that one's knowledge of the mechanisms of both the formation of DENs and their roles in catalytic reactions is improved by understanding the relationship of composition structure function, because most of the catalytic reactions are compositionally- and structurally-sensitive.
CO direct dissociation was found to be structurally most sensitive, whereas CHx hydrogenation is structurally least sensitive.
For each gene, we constructed a 2 × 2 contingency table by categorizing each 4-fold degenerated sites as structurally sensitive/non-sensitive and as evolutionarily conserved/non-conserved (Additional file 2: Table S1 for an example).
All above analyses were based on categorized data, such as a classification of all nucleotide sites into conserved/non-conserved or structurally sensitive/non-sensitive. Weighted entropy and structural sensitivity are continuous quantities.
We have extended these preclinical studies to the human volunteers by examining the effects of lamotrigine and 4030W92, two structurally related voltage-sensitive sodium channel antagonists, on acute sensory thresholds and facilitated processing induced by intradermal capsaicin.
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