Although there is little 2-D similarity, using the PubChem fingerprint, substantial 3-D similarity is found between various structurally diverse anti-inflammatory drugs.
However, the ability of PXR to promiscuously bind to various structurally diverse compounds may cause targeting ligand-mediated PXR activation to be a promising yet intricate task to complete.
Various structurally diverse anti-epileptic drugs are available for the treatment of epilepsy, but ∼30% of people with epilepsy do not respond satisfactorily to many of the first-line treatments, and substantial side effects are widely documented.
Experiments aiming at determining the structure activity relationship (SAR) or reverse medicinal chemistry approach to classify the effect of various structurally diverse compounds on the heartbeat or the spectral profile it generates can be easily adapted to this model.
The newly identified inhibitors are structurally diverse and have various chelating groups for the active-site ferrous ion including sulfonamide, carboxylate, N-benzo[1,2,5]oxadiazol-4-yl amide, and 2-[1,2,4]triazolo[3,4-b]][1,3,4]thiadiazol-3-yl-quinoline ][1,3,4]thiadiazol-3-yl-quinoline ][1,3,4]thiadiazol-3-yl-quinoline ][1,3,4]thiadiazol-3-yl-quinoline
They are structurally diverse and can have various chemical compositions mainly consisting of fatty acids, glycolipids, lipopeptides, lipopolysaccharides and lipoproteins depending on the producing microorganism, raw matter and process conditions.
Various kinds of structurally diverse terminal alkynes including aromatic, heteroaromatic, aliphatic, double bond-containing, silylacetylene, propargylic alcohol, and propargylic amine derivatives could selectively be converted into the corresponding diynes in the presence of I.
The present bifunctionality could be applied to chemical fixation of CO2 even at atmospheric pressure with various kinds of structurally diverse aryl diamines, primary monoamines, propargylic alcohols, and propargylic amines into cyclic urea derivatives, 1,3-disubstituted urea derivatives, cyclic carbonates, and cyclic carbamates, respectively.
We find that all network properties offer support to the superiority of the GEO-3D network model to a large number of RIGs that correspond to a wide range of structurally diverse proteins, constructed using various contact types and a wide range of distance cut-offs.
Recent studies have also demonstrated that AhR can bind and be activated by structurally diverse chemicals, such as various phytochemicals [ 34, 52], Malassezia metabolites [ 45], and photo-induced chemicals [ 9, 93, 94] with a wide range of affinities.
