We demonstrated that the ovarian surface epithelium is the precursor tissue for these ovarian carcinomas, and that introduction of oncogenes causes phenotypic changes in the ovarian surface epithelial cells.
For renal regeneration, both human precursor tissue(Dekel et al. 1997; Dekel et al. 2002; Dekel et al. 2003) or murine fetal kidney cell transplantation(Kim et al. 2007b; Kim et al. 2007a) can be utilized.
Bone wound healing associated with implant osseointegration undergoes intramembranous bone formation without cartilage precursor tissue [3], [4]; therefore the expression of cartilage ECM molecules during osseointegration was a puzzling observation.
The early development of the mammalian metanephros, the direct precursor tissue of the adult kidney, is a complex process that involves highly regulated interactions between two derivatives of the intermediate mesoderm, the wolffian duct and the metanephric/nephrogenic mesenchyme.
We have previously shown that implantation of pig embryonic spleen precursor tissue can correct hemophilia in factor VIII KO NOD-SCID mice by providing the necessary Factor VIII[11].
The results show that maximal growth potential is found upon implantation E42 old skin precursor tissue (initial size vs final size: 1 to 2 mm2 vs 47 mm2) while tissue harvested at later time points are gradually lose their capacity to grow (Figure 5).
