Sentence examples for pharmacologic administration from inspiring English sources

Previous studies have shown that MTA exerts remarkable biological effects, its pharmacologic administration modulates different pathways and cellular responses, including gene expression, cell cycle progression and inflammation [15] [20].

The ability to increase lifespan adds to a growing list of other beneficial effects that pharmacologic administration of FGF21 has in mammals, including insulin sensitization, normalization of glycemia, and reduced body weight in obese animals (Potthoff et al., 2012).

For example, ameliorating ER stress of obese mice through genetic overexpression of UPR components ATF6 [ 252], XBP1 [ 194], or ER chaperone proteins GRP78 [ 253], ORP150 [ 254], or pharmacologic administration of ER stress inhibitor tauroursodeoxycholic acid (TUDCA) [ 195], all improved glucose tolerance, insulin signaling, and related lipid disorders.

This study compared the pharmacologic profile of administration of insulin aspart by jet injection to that by conventional insulin pen.

In rodent models, plasticity can be elicited by reducing intracortical inhibition through pharmacologic treatment with administration of antidepressants [ 5, 67].

The paucity of pharmacologic information regarding colistin administration in the critically ill highly impedes the creation of optimal dosing regimens that reconcile adequate antibacterial activity with minimal toxicity.

The blood concentrations of AAP-Cl in rats showed a biexponential decline following intravenous administration of pharmacologic doses ranging from 10too 100 mg/kg in rats.

Future approaches may include (1) other types of systemic pharmacologic therapy; (2) intravesical administration of drugs, including blockers of afferent input; (3) intradetrusor injection of botulinum toxin; (4) the use of tissue engineering to simplify augmentation cystoplasty; (5) genetic interventions to reverse neuroplasticity changes; and (6) combinations of these approaches.

The concentration of study compounds is in the nano- to micromolar range and is within pharmacologic range following systemic administration.

Cardiovascular support during resuscitation may require administration of pharmacologic vasoactive agents with vasopressor and/or inotropic actions after blood volume is restored [ 40].

Because the GLP-1R agonists have not been used long term in humans, the potential side effects of long-term administration of pharmacologic concentrations should be evaluated.