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Pharmacologic response to quinidine, digoxin, propranolol, and adenosine has been reported.
Biomarker (biological marker) is a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic response to a therapeutic intervention.
Due to the often pleiotropic nature of their action, in order to design meaningful nonclinical safety assessment studies, the practicing toxicologist must be able to differentiate between an exaggerated, but expected pharmacologic response and toxicity associated with their administration.
In summary, the evidence for heteromeric TASK-1/TASK-3 complexesomplexes together with an altered pharmacologic response to TASK-1 blockers in vitro is likely to have further impact for studies isolating ITASK-1 from cardiomyocytes and for the development of drugs specifically targeting TASK-1 in atrial fibrillation treatment.
Thus it is of interest to limit our definition of response to true pharmacologic response rather than placebo response.
Key predictions emanating from the model simulations were validated by in vitro pharmacologic response patterns.
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However, the body of literature on programming these stimuli-responsive nanomaterials to attain the desired level of pharmacologic responses is still fragmented and has not been systematically reviewed.
Further work showed the effects of antidepressant treatment on depressive disorders seen in the course of alcohol and drug dependence, the characteristics of placebo and the specific true pharmacologic responses to medication (a technical tour de force), and innovative studies combining antidepressants to more rapidly relieve suffering from these devastating disorders.
These platforms can allow precise control of the environment surrounding individual cells and they have been used to study physiologic and pharmacologic responses at the single-cell level.
A commonly used definition of a biomarker is "a characteristic that is objectively measured and evaluated as an indicator of normal biological process, pathogenic processes, or pharmacologic responses to a therapeutic intervention" [5].
We identified several new candidate transcripts that could enable us to better understand sex specific differences in the occurrence and pharmacologic responses of kidney injury in humans.
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