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Based on the frequent pharmacologic dosing and potentially indefinite treatment period required for cCH, important challenges of prophylaxis include the potential for drug interactions and drug-related adverse events including atrioventricular conduction abnormalities, tremor, and confusion [18].
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It is possible that if we had included the pharmacologic doses (1000 μg L−1) in the histological testing, we may have detected an effect of phytoestrogens on the gonads.
Pharmacologic doses of these two blocking agents might have displaced radioligand bound to plasma proteins, thus indirectly increasing brain uptake, but such was not the case.
It was reported that low (5 × 10-7 M) concentrations of genistein caused increased proliferation of PC-3 cells whereas a pharmacologic dose (5 × 10-5 M) decreased proliferation.
We tested the hypothesis that pharmacologic doses of branched-chain amino acids would improve the early metabolic response after major cancer surgery.
The blood concentrations of AAP-Cl in rats showed a biexponential decline following intravenous administration of pharmacologic doses ranging from 10too 100 mg/kg in rats.
Although erythropoietin (EPO) deficiency is not responsible for the anemia of myelodysplasia, pharmacologic doses of recombinant human EPO (rHuEPO, epoetin alfa) and epoetin beta have been studied extensively as treatment of anemia in myelodysplastic syndrome (MDS).
Pharmacologic doses of vitamin C given IV may produce drug effects in many body tissues, mediated by hydrogen peroxide formation in extracellular fluid but not blood [18] [20].
Despite the clinical dogma that "AIS is not treatable," some sporadic PAIS and MAIS patients respond to endocrine management consisting of pharmacologic doses of androgens [6] [9].
NC-TDI is a surrogate of ligand-receptor binding stability, thus such mutations can be rescued by using conditions that increase ligand-receptor binding stability, such as use of pharmacologic doses of natural or synthetic ligands.
We hypothesized that pharmacologic doses of rIFN-γ1b could augment the host immune response in TB, and to evaluate this we conducted a 4-month randomized, controlled clinical trial with rIFN-γ1b at 200 µg/day for three days/week with three arms: nebulized rIFN-γ1b or subcutaneous rIFN-γ1b with DOTS versus DOTS alone.
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