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The distributed toggle switch relies on mutual repression of the two strains, and oscillator is comprised of two strains, one of which acts as an activator for another that in turn acts as a repressor.
For example, in contrast to the mutual repression of Wg and BMP seen in leg discs, elevated Dpp actually induces wg expression during gut development [48].
The suggested mechanism of the mutual repression of PPAR and NEMO/NF-κB regulators during their coordination of the transition from early to the late phase of HF-response remains to be confirmed by biochemical studies.
In contrast, we have focused on oligomerization in positive-feedback autoregulatory circuits, as well as genetic toggle switches based on the mutual repression of genes [ 15].
Mutual repression of signalling between NFκB and ER has been reported in various in-vitro systems (Harnish et al., 2000; Feldman et al., 2007; Quaedackers et al., 2007).
We therefore generated dfmr1 mmp1 double null mutants and similarly found the same mutual repression of both classes of null mutant phenotypes, which is consistent with the TIMP overexpression analyses.
Similar(54)
Mutual repression circuitry of this type can contribute a switch-like function: EcR activity lowers miR-965 activity, which allows greater EcR expression/activity by alleviating miR-965 mediated repression.
The data are in Figure 6 figure supplement 2. Mutual repression circuitry of this type can contribute a switch-like function: EcR activity lowers 965 activity, which allows greater EcR expression/activity by alleviating miR-965 mediated repression.
In wild type, there were no combinations with four or more genes and only four out of 20 possible combinations of three genes, consistent with the strong mutual repression between some of the gap genes (reviewed by Jaeger, 2011).
These two genes are initially co-expressed in the pancreatic primordium and their domains segregate, not as a result of mutual repression, but through the opposite effects of Notch signaling, maintaining nkx6.1 expression while repressing ascl1b in progenitors.
Increased activation of Kr by Bcd must be balanced by increased activation of gt by Bcd to maintain balance of mutual repression between Kr and gt.
Related(20)
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