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Exact(5)
For example, despite the mutually exclusive nature of K27M and G34 mutations, which implies a common pathway or biological process, there are important differences.
Thus, the local duplicate has a higher chance of being removed through accumulation of degenerative mutations, which implies a higher level of Ka/Ks.
Woodruff et al. [ 35] approached the issue of "clustered mutations", which implies that related individuals may inherit identical genetic changes, contrasting an assumption that mutations are independent events.
The replicative DNA polymerase, pol III, may have been responsible for these mutations, which implies that at least occasionally pol III can bypass G[8,5-Me]T, even though a role for pol I cannot be ruled out.
The null hypothesis for this test is that the observed sequence differences are due to convergent mutations, which implies that all PHI values are similar for all pairs (i.e., the PHI values do not vary with the physical distance between residues).
Similar(55)
Approximately, one-third of CRCs have been reported to have activating K-ras mutations, which implied insensitivity to EGFR inhibitors.
The MIC variation for ciprofloxacin differed 2- to 4-fold in isolates that had the same QRDR mutation profile, which implies that other mechanisms might partially contribute to the resistance phenotype (online Appendix Figure).
There was no difference between the CPSC of Type 1 and Type 2 VHL disease mutations, or in the proportion of mutations which involve interface residues, implying no clear functional difference between missense mutations described in Type 1 and Type 2 VHL diseases.
However, there was also a single case in which DNMT3A was lost at relapse and the NPM1 mutation was maintained, which implies that the mutation order is not strict.
In recent work by Neiman et al. [ 91], direct evidence for a link between asexuality and mutation accumulation was obtained, which implies that mutational buildup could be rapid enough to contribute to the short-term evolutionary mechanisms that favor sexual reproduction.
We will now have
Related(15)
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Justyna Jupowicz-Kozak
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