Sentence examples for mutations which leads from inspiring English sources

Subtype 6.1 specifically deals with dysregulation of PTEN in the absence of BRAF mutations which leads us to consider AKT/PI3K inhibitors as potential therapies for this subtype.

Subtype 6.2 specifically deals with dysregulation of Akt in the absence of BRAF mutations, which leads us to consider AKT/PI3K inhibitors as potential therapies for this subtype.

The ability of microbes to undergo mutations which leads to resistant strains of the organism has been well-documented in the world of microbiology.

HCV is an enveloped, single-stranded RNA virus which is prone to a lot of mutations which leads to constant alteration of its phenotype and formation of new quasispecies [ 5].

In contrast, smaller populations become fixed for a wider range of possible beneficial mutations which leads to increased variation in adaptive trajectories across populations and allows some populations to avoid becoming trapped on local peaks.

Furthermore, the ratio of TYR to filaggrin degradation products is higher in AD FLG when compared to CTRL and AD NON-FLG, suggesting either accumulation of TYR in the SC or alternative pathways in AD patients with FLG mutations which leads to elevated TYR levels.

Many of the mutations, which lead to these characteristics, will confer a survival benefit on the mutated cells, and lead to clonal expansion at the expense of other cells.

The found that 21 separate "graffiti signatures" could account for 97% of the mutations which led to cancer.

X-ray repair cross-complementing group 3 (XRCC3) is responsible for maintaining the integrity of the genome, playing a critical role in protecting it against mutations which lead to cancer.

In a previous recent work, we determined in vitro that MRS-deficiency accelerates the acquisition of mucA [30] and lasR [31], [32] mutations, which led us to the hypothesis that such an association may also be occurring in vivo.

The WS genotype is not static either, as WS genotypes are known to accumulate measurable metabolic defects and reduced fitness within 100 generations, whilst compensatory adaptation (mutations which lead to an increase in fitness) in WS lineages has been seen within a similar interval in liquid microcosms [25].