Sentence examples for mutations which results from inspiring English sources

IL-6 levels are elevated in lung cancer patients in cells lines with endothelial growth factor receptor (EGFR) mutations which results in STAT3 elevation [110].

In contrast, most repetitive elements have lost their functional activity and evolve neutrally by accumulating random mutations, which results in much weaker evolutionary conservation in these sequences [ 20].

A passenger mutation fixes predominantly by interference from other stronger mutations, which results in a fixation probability Gpass (see Equation A8).

It has been estimated that about 50% of melanomas contain MAPK pathway activating mutations, which results in considering it the most important therapeutic target [ 10].

We therefore hypothesise that the progenitor cells within this population are more epigenetically unstable, regardless of their association with potentially epigenome-modifying genetic mutations, which results in hypermethylation of tumour suppressor genes, giving selective advantage and causing transformation.

Sequences from WS differ mainly by singleton mutations which results in a star-shaped genealogy typical of a selective sweep while a single sampled lineage survived to the sweep.

The sequence analysis revealed a total of 16 point mutations which resulted in amino acids substitutions across the three genotypes (Table 4).

The CIP patients, characterized by lack of nociceptive perception, are mostly inflicted by Nav1.7 nonsense mutations, which result in premature protein truncations and inability to produce functional sodium channels.

We filtered the complete set of mutagenesis data from SWISS-PROT release 56 for single amino acid substitution mutations, which resulted in a dataset containing 20787 mutations.

This observation is expected because indels in coding regions can lead to frameshift mutations, which result in a truncated protein that may be hyper-, hypor, or neomophic explaining the high negative selective pressure in coding regions.

One out of billions of cells acquires a mutation, or several mutations