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For example, when a hairpin structure that controls the expression levels of the MS2 coat protein was mutated, compensatory mutations were recovered that restored the hairpin [ 37].

In contrast, silent, missense, and splice junction mutations were recovered in an equivalent proportion as predicted (Table 3).

In contrast missense, stop and splice junction mutations were recovered in a slightly lower proportion than predicted (Table 2).

Only nine binding pocket mutations were recovered without other inactivating changes in fur among the 62 transformants screened; each such mutation conferred less resistance than did a Δfur allele (Fig. 4C); and two of them (furH42L and furH42V) caused slow growth.

Fub mutations were recovered by targeted mutagenesis following a hypothesis-driven experiment (see below).

These four intragenic suppressor mutations were recovered multiple times in the M1 population (Table 1).

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The constraints of active-site geometry in these later steps of the reaction pathway will result in mispair-specific preferences that determine which mutations are recovered at high frequency; note, for example, the predominance of mutations resulting from wobble (Pu-Py) mispairs in Table 6.

Live heterozygous mice carrying the L100P mutation were recovered by in vitro fertilization of C57BL/6 J eggs with the cryopreserved sperm of the corresponding G1 progeny.

Each mutation is recovered over a balancer chromosome.

If a Top2 mutation was recovered that affected pairing, then altered wing and body pigmentation would be expected.

In December of 1982, the first such mutation was recovered from a hybrid dysgenesis screen and eventually acquired the name, Inverse regulator-a[hd1] (Rabinow et al. 1991).

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