Sentence examples for mutations were selected from inspiring English sources
Consequently, this marker was excluded for further analysis, and the KRAS, BRAF and PIK3CA mutations were selected for combined mutational analysis.
Earl and Deem found that larger mutational shifts (recombination/swapping rather than point mutations) were selected for, and became dominant, when landscape shifts occurred faster and/or were larger.
(a) Endogenous, native mutations were selected for further study based on frequency and location.
Four lines of evidence suggest that these mutations were selected because of their fitness advantage on glucose rather than general adaptation to laboratory conditions.
As a control group 59 tumors with p53 missense mutations were selected by matching with the p53 null tumors on the basis of patient age at diagnosis, stage and grade of cancer, cancer site, and year of diagnosis.
To test the consequences of subtle structural alterations remote from the RdRp active-site, the following single point mutations were engineered in the WNV NS5 RdRp coding region: T363N, A365N, and T537I; these mutations were selected in an effort to stabilize the secondary structural elements near the rNTP binding pocket of the RdRp.
However, the mechanism may not be straight-forward, with some deleterious mutations being selected against (purifying selection), and some possibly undergoing positive section [24].
Ultimately, oncogenic mutations are selected from a mutated population.
In sequences that have evolved under positive selection, the number of retained mutations is closer to those that arose by mutation than under purifying selection where amino acid replacement mutations are selected against.
HBX inactivating mutations are selected in HCC tissues suggesting specific pressure of selection during hepatocarcinogenesis.
Some of those mutations are selected by host immune responses and often cause viral fitness losses.
