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Exact(5)
Thus, cut-off values for detecting resistance mutations were individually calculated for every sample using a Chi-square test with correction for continuity.
Next, all single-point mutations were individually investigated according to the domains.
All mtDNA mutations were individually analyzed using the MitoAnalyzer (National Institutes of Standards and Technology, Gaithersburg, MD, USA, http://www.cstl.nist.gov/biotech/strbase/mitoanalyzer.html) and the MITOMAP database [ 20].
(A ) Genes containing causal mutations were individually deleted in E6-1 and tested for oscillations after applying the standard synchronization protocol to an unsynchronized culture.
MM72, MM73 and MM78 strains were obtained from a mutant library generated by mini-Tn5Km2 transposon insertion [ 31] and in the present study these mutations were individually transduced into a fresh C. crescentus NA1000 background.
Similar(54)
Gradual emergence of H2H mutations in the three decades after the Spanish influenza pandemic suggests that many of these adaptive mutations are individually not essential.
This model does not imply that any of the 1918 mutations are individually sufficient, or necessary, for human-to-human transmission.
A particularly interesting form of this phenomenon, sign epistasis, occurs when several mutations are individually neutral or deleterious but their combination is beneficial [ 7].
Although such mutations are individually rare, in 2014 the European Union granted approval to ivacaftor for the treatment of people with one of eight other non-Gly551Asp gating CFTR mutations.
In the infection complementation assay, the A73D and A74D mutations were tested individually and in combination.
For this purpose, the mutations were introduced individually at the chromosomal WSC1 locus and the strains obtained were tested in drop dilution assays for their growth under different stress conditions.
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