Sentence examples for variants were individually from inspiring English sources

In this study neither the IL12A rs568408 nor the IL12B rs3212227 polymorphic variants were individually associated with anti-HBs development in the examined HD patients as was shown for IL18 rs360719 CC.

Compound heterozygotes are expected to occur more frequently than homozygotes, especially when variants are individually rare.

Although these rare variants are individually difficult to detect, they can collectively contribute substantially to the genetic risk underlying complex traits (35).

Although these rare variants are individually difficult to detect, they can collectively make a substantial contribution to the genetic risk underlying complex traits.

Although the risk of CRC associated with each of these common variants is individually modest, they make a significant contribution to the overall disease burden by virtue of their high frequencies in the population.

The absence of significant findings from genomewide linkage studies suggests that the effects of DNA risk variants are individually very small despite the high heritability of ADHD (Faraone et al. 2008).

Because most variants are individually rare, achieving adequate statistical power requires a design where additional copies of the variant of interest can be sampled (perhaps in a family study or in a founder population) or the ability to combine and evaluate groups of variants likely to have similar function (86).

Control subjects had not been tested using chromosome microarrays, but as pathogenic structural variants are individually rare even in populations enriched for them and even less common in healthy individuals (Helbig et al., 2009; Itsara et al., 2009; Heinzen et al., 2010), it is unlikely that bias resulted from lack of screening in control subjects.

We observed three synonymous and ten non-synonymous variants that were individually examined for potential effect on the activity of CYP2D6.

We also created and summarised a linear model containing all the variants that were individually significantly associated with BMI.

To verify the consistency of variant calling, polymorphisms were individually checked with the Integrative Genomics Viewer (IGV) software [ 63].