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Exact(11)
Most mutations that were predicted to disrupt the secondary structures fail to replicate, while compensatory mutations were allowed replication to resume.
Mutations were allowed in all historical generations for all loci with a mutation rate of 1.25×10−3 per locus, per generation, and per animal.
At the highest temperature of 0.6, the reverse polymerizing organisms are unable to establish themselves the same as when mutations were allowed, implying that this inability to compete with forward polymerizing organisms during exponential growth is a consequence of the spontaneous hydrolysis penalty and is not affected by the presence or absence of mutations in the system.
We noted that the results of this last experiment seemed to indicate that, when mutations were allowed, their might be a temperature regime in which there is a transition between an equilibrium of organisms containing forward and reverse polymerases and a complete dominance by organisms containing the forward polymerase.
We noticed that the decline in population of reverse polymerizing organisms when starting from a full environment is roughly exponential, so we plotted the natural log of this number against simulation time in figures 7, A & B for simulations where mutations were allowed in the system or where they were prohibited, respectively.
The alignment of sequences was unnecessary because only point mutations were allowed to occur during a simulation.
Similar(49)
Docking simulation for up to five mutations is allowed, and the Curated Kinase Docking procedure will be executed.
Here, I consider the case when back mutations are allowed.
We assume that no non-synonymous mutations are allowed, so that all variation in usage is due to synonymous mutations.
The effect of neutral mutations on the number of accessible pathways is even more dramatic when back mutations are allowed.
As with allowing neutral mutations, the effect of allowing double mutations on the number of accessible pathways is more pronounced when back mutations are allowed.
Related(20)
moves were allowed
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Justyna Jupowicz-Kozak
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