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Exact(6)
For example, we found that the agreement among SIFT, PMUT, and PolyPhen in predicting the impact of mutations was only
The penetrance associated with truncating mutations was only marginally significant.
The codetection of two mutations was only detectable with highly sensitive methods.
In the present study the 299/399 TLR4 haplotype, when present without TIRAP/Mal mutations, was only weakly associated with susceptibility and course of disease in both groups.
In BRCA2 we found evidence that the population frequency of the most common haplotype in individuals carrying deleterious mutations was greater than 95%, when the corresponding frequency in those without deleterious mutations was only 65%.
But recently, Liao and colleagues emphasized that the prognostic impact of PI3KCA mutations was only restricted to the small proportion of CRCs harboring concomitant mutations in both exon 9 and 20 19.
Similar(54)
Comparison to estimates of this quantity suggests that, as expected, recessive lethal mutations are only a subset of the recessive mutational burden.
Tumor mutations were only found in one of them.
In current clinical practice, gene mutations are only classified as being present or absent, ignoring the clonal complexity of cancers.
These mutations are only observed in a minority of patients and families, [9, 10] suggesting the presence of mutations in additional genes, which remain unknown at present.
In contrast, the inhibitory effects of TGFbRII and ACTRIIA mutations were only observed in the cells stably expressing the receptor mutants, suggesting a possibly involvement of other unidentified mechanisms that require further investigation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com