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Most of these mutations occurred only once in their study population.
Dutton-Regester et al. [4] observed that ERBB4 mutations occurred only in 2% of melanoma cases in Australia.
In QRDR of gyrA, missense mutations occurred only in codons 83 (conversion of serine to phenylalanine (S83F), tyrosine (S83Y), and isoleucine (S83I)) and 87 (conversion of aspartic acid to glycine (D87G), tyrosine (D87Y), and asparagine (D87N)).
Interestingly BRAF mutations occurred only in polyps with the serrated architecture supporting that BRAF activation is pivotal in the serrated pathway of CRC as advanced previously by Jass [ 19, 20] and other authors [ 13, 14, 21, 22].
T → C mutations occurred only in the 3 5% and 5 7% frequency for O-Me-dT and O-POB-dT, respectively, but they dropped significantly in pol IV- and pol V-deficient strains.
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Moreover, this variant is the only TPI variant found homozygous among affected individuals; all other mutations occur only in the compound heterozygous state together with the Glu104Asp variant or with an obvious TPI null allele ([2] and Fig. 1).
Substantially beneficial mutations occur only on their sigmoid slopes, i.e., in narrow ranges of r.
In addition, PPM1D, H3.1-K27M, ACVR1CVR1 mutations occur only in PAX3-Low tumors.
A more recent study has reported that PIK3CA mutations occur only in high grade endometrioid or high grade CCCs [ 46].
54 Some mutations occur only in the Asian population, where the G2019S seems to be rare or absent.
Models of resistance evolution within a pest population are based on the premise that resistance mutations occur only rarely, but are strongly favored in insecticide treated environments.
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