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Tumor mutations were only found in one of them.
In contrast, the inhibitory effects of TGFbRII and ACTRIIA mutations were only observed in the cells stably expressing the receptor mutants, suggesting a possibly involvement of other unidentified mechanisms that require further investigation.
The codon 61 mutations were only found in samples from the >70 age group.
Some RTI (K65R, L74V) and PI (D30N, M46I/L, I84V) mutations were only seen in subtype B isolates.
Mutations were only found in the coding regions of the pyrF and pyrE2 genes and a number of mutants had mutations in more than one gene (Table 1).
In all five patients where matched and constitutional DNA was available, the mutations were only somatic.
Similar(28)
Researchers are quick to point out that de novo mutations are only part of the autism story.
In current clinical practice, gene mutations are only classified as being present or absent, ignoring the clonal complexity of cancers.
But apart from certain founder populations, the frequency of BRCA2 mutations is only ∼1 in 800 (ref. 10), requiring a somewhat extraordinary coincidence.
Noteworthy, SPOP mutations are only found in about 12% of primary PCa and only 7% of metastatic CRPC, while TRIM24 was recently shown broadly upregulated in CRPC19, suggesting additional regulatory pathways that are particularly important in aggressive PCa.
In other words, the passenger mutations are only along for the ride.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com