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Exact(6)
For most species, the overall rate of harmful mutations was much less than 0.5 per individual per generation, the researchers report in the 13 October issue of Science--too low to justify sexual reproduction.
Within BGp, the predominance of W→S mutations was much weaker.
However, the ratio of genes with silent mutations was much more abundant (55 58%) than that of genes with non-silent mutations in both SBs and NSBs.
However, among cancer patients of Caucasian ancestry, the prevalence of gene mutations was much higher compared with those previously published for the general population.
The percentage of point mutations was much higher in exon 1 (50.7%) than in exon 2 and 3 (29.6 and 23.1, respectively).
We estimate that mutagenic efficiency (i.e., rate of conversion of adducts into mutations) was much lower for Pig-a compared to lacZ, and speculate that this difference is likely explained by differences in repair capacity between the gene targets, and differences in the cell populations sampled for Pig-a versus lacZ.
Similar(54)
Overall, the prevalence of mutations is much higher in mitochondrial aaRSs, and the two most often mutated aaRSs are mitochondrial glutamyl-tRNA synthetase and dual localized glycyl-tRNA synthetase.
Deleterious mutations are much easier to study than beneficial mutations.
Men with any of these 14 mutations were much more likely than those without to develop an advanced, invasive form of cancer which spread to the lymph nodes or other parts of the body, and to die from the disease.
Transverse mutations are much less frequent than the transition mutations and will affect these equations to a smaller extent.
In the present investigation HRAS mutations dominated over KRAS mutations and HRAS codon 61 mutations were much more frequent than codon 12 mutations, which is in line with most previous investigations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com