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Consistent with this, Smith et al. noted that some mutations caused much greater antigenic change than others, i.e., that the long-term rate of antigenic change was less uniform than the rate of genetic evolution [ 18].
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The severe P525L mutation caused much higher levels of FUS recruitment, which was detectable in all SGs analyzed (Fig. 4D and supplementary material Fig. S8).
In this context, it becomes interesting to entirely reappraise the discovery of "adaptive mutations", which caused much controversy 20 years ago because they were (wrongly) interpreted as suggesting Lamarckian evolution (Cairns et al. 1988; Danchin 1988).
The mutations we have studied caused much larger changes in IP3 sensitivity (∼30-fold, Table 4).
Therefore, these two point mutations may cause much drastic changes in the stability and activity in Wov and induce more trichome formation.
This announcement caused much controversy.
This case study further suggested that a defect in mitochondrial fission may have more severe consequences than those of fusion defects, since the Drp1 mutation caused a much earlier onset (prenatal) and fatal outcome.
However, surprisingly, the same mutations caused YFP levels to vary as much as 100-fold when E. coli cultures ran out of the cognate amino acid in the growth medium.
Numbers of non-synonymous mutations caused by transformation and mutagenesis were much less than those between japonica rice cultivars Koshihikari (794 genes) or Omachi (1017 genes) and Nipponbare.
Our focus is cancer which arises from genome mutations caused by ROS.
Moreover, several of the long-term populations evolved defects in their DNA repair, causing much higher mutation rates [ 18, 26, 52].
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