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In general, buried mutations exhibited much more profound detrimental effect on enzyme folding and activity compared to the solvent-accessible mutations.
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Furthermore, the Y808E mutant carrying six aspartic acid mutations at the juxtamembrane phosphorylation motif exhibited much higher GC activity than that of Y808E, even though WT-GC-B containing the same six aspartic acid mutations exhibited only trace level of GC activity.
India exhibited much of the same self-satisfaction.
Picture books exhibited much more originality than did teenage literature.
Thus, ghd10 exhibited much later flowering time than the wild type under both SD and LD conditions, and the flowering time delay was more obvious under LD conditions, which indicated that the Ghd10 mutation may have a more severe effect on flowering time under LD conditions than under SD conditions.
Specific loci however, exhibited much greater variability.
In contrast, Sc1 (ALG9) exhibited much higher fluctuations of FC values.
Tumour specimens exhibited much higher levels than normal lungs.
Individuals with GJB2-associated deafness who harbour two nonsense/truncating mutations exhibit a much more severe clinical phenotype, and hence are more likely to come to clinical attention, than those harbouring two missense mutations (Azaiez et al. 2004).
The double phospho-mimicking rrm3-6SD pif1-12didutanotdid not exhibit much better survival of HU compared to rrm3-6SD alikelylikely because the phospho-mimicking mutations in PIF1 did not fully resemble a constitutively phosphorylated gene product.
The derived viral strains carrying the mutations exhibited a variety of distinct plaque phenotypes.
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