Sentence examples for mutations to wild from inspiring English sources

The increase in viral load coincided with a few reverse mutations to wild type at positions 114 and 302 (Figure 5B) and escape mutations from the wild type at amino acid positions 242 and 370 (Figure 5C).

Most reverse mutations to wild type in subject E-3430 occurrearlyrly and were pre-existing, resulting in a quick elimination of alternative amino acids from the pool of viral quasispecies (e.g., amino acid positions 42, 92, 141, 151, 298, 341, 411, 412, 414, 431, 443, 449, 459, and 462 in Figure 4B).

Recessivity of the majority of the mutations to wild type identified recessiveness as the default state and dominance as representing a minority or exceptional state.

A change in KRAS gene mutational status was observed in 13 cases (12.3%): five patients (4.7%) changed from wild type to codon 12 mutations, six patients (5.7%) changed from codon 12 mutations to wild type and two patients (1.9%) changed from codon 13 mutations to wild type (concordance, 87.7%; κ = 0.747; 95% CI, 0.617 0.876).

The effects of the individual mutations on IR resistance in the Founder Δe14 background were echoed by the effects of reverting these same mutations to wild type in the CB2000 background.

The reversion of resistance mutations to wild-type codons appears to follow a predefined pattern, based on the prevalence of RAMs and mutation linkage.

The aim of this study was to describe the mechanisms of reversion of RT mutations to wild-type viral population during STI and the relationship with replication capacity (RC) as a measure of fitness.

However, the extent of reported genotypic changes during STI differs between studies, and only a few of these studies described the patterns of reversion of mutations to wild-type codons, which occur as a combination of re-emergence of preexisting variants with fewer resistance mutations and actual reversion of codons within a viral genome.

Mutation can occur in two directions; mutation from wild type to mutant is called a forward mutation, and mutation from mutant to wild type is called a back mutation or reversion.

Dynamics of viral quasispecies at position 90 revealed a phenomenon of reverse mutation to wild type virus followed by escape mutation from the wild type.

For the generated haplotypes, we define the level of noise as equal to the probability of randomly altering an allelic value from wild type to mutation or from mutation to wild type.