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Exact(6)

The spectrum of IDH1/IDH2 mutations is available elsewhere [ 24].

A list of these mutations is available from the bitbucket repository https://bitbucket.org/readbiomed/mutationtoolcomparison.org/readbiomed/mutationtoolcomparison

Although genetic testing for BRCA1 and BRCA2 mutations is available, it is expensive, time-consuming and stressful to patients.

The table describing all the identified mutations is available in the paper of Ding et al. (2008), but the patient-specific gene sequences are not.

Although an extensive collection of mutations is available at these sources, the distribution of these mutations and variations within the gene or peptide, along with common SNPs is not easily accessible or evident.

A public database enlisting the reported mutations is available at the Leiden Open Variation Database (LVOD, http://www.ncbi.nlm.nih.gov/lovd/home.php?select_db=ABCC6), while neutral variants can be found in dbSNP (http://www.ncbi.nlm.nih.gov/SNP/).nih.gov/SNP/

Similar(54)

Presumably, different mutations were available in each population for natural selection to work on.

Several known mutations are available that drastically reduce or obliterate development of major structural traits, for instance.

Over 10,000 mouse strains and more than 20,000 mouse ES cells containing gene-trapped or targeted mutations are available to researchers.

Clinical characteristics of the families and description of the mutations were available upon request.

As a result, there are some protein kinases with the known WT crystal structure and known SNPs, yet no mutational models could be generated, because either all known mutations reside outside of the resolved crystal structure of the kinase catalytic domain or only synonymous mutations were available.

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