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However, whether correction of HERG nonsense mutations is possible is unknown.
We have designed a genotyping assay based on polymerase chain reaction and DNA-Chip for HBV Starting from a unique specimen, analysis of polymorphisms at 150 positions along the genome and 383 mutations is possible as well as the determination of the genotype.
The transmission of somatic mutations is possible through vegetative propagation, leading to non-chimeric or to chimeric plant structure (Marcotrigiano, 1997; Klekowski, 2003) and a mosaic state (i.e. initial cells associated with mutated cells) (Gill et al., 1995; Santelices, 1999; Pineda-Krch and Lehtilä, 2004).
Taken together, these cases show that heterozygous loss-of-function mutations in SF-1 (NR5A1) can be found in children with severe forms of hypospadias and that male sex of rearing of children with SF-1 mutations is possible, but SF-1 mutations are not found frequently in association with minor forms of hypospadias.
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However the p53 gene has mutational hotspots, germline mutations are possible, and certain subtypes, such as basal-like tumors, have a greatly elevated p53 mutation rate [ 14], presenting a risk for misclassifications.
One-, two- or multiple-point mutations are possible by specification of residues to be mutated and the required substitutions.
"None of those take into account the fact that compensatory mutations are possible," she says.
In the hand-microdissected samples, confident identification of mutations was possible in several cases only after band excision, DNA elution, reamplification, and verification of mutant enrichment by a second SSCP analysis prior to sequencing.
Both point mutations and major mutations are possible.
The evolutionary process was continued until no further mutations were possible.
The secondary mutations are possible because a large cell population within the colony is subject to standard mutation rates.
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