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The underlying molecular mechanism of prion diseases associated with each of these mutations is unclear.
The functional significance of these mutations is unclear.
The significance of these mutations is unclear and needs to be investigated further.
The therapeutic choice for the patients with more than one driver mutations is unclear.
Owing to the confounding presence of tubulin pseudogenes, however, the clinical significance of these mutations is unclear [ 49].
Any functional significance for the absence of exon 1 mutations is unclear and could reflect the small sample size of POH patients.
Similar(48)
The benefits of immune checkpoint inhibitors for first-line treatment in patients with lung adenocarcinoma harboring EGFR mutations are unclear.
However, the epidemiology and mechanisms underlying mutagenesis of doublets and multiple mutations are unclear.
Because the mechanisms of cochlear pathogenesis caused by Cx mutations are unclear, we investigated effects of Cx30 null mutation on GJ-mediated ionic and metabolic coupling in the cochlea of mice.
Until now, the function of the class 2 mutations was unclear.
Within FBC, the prevalence and prognostic significance of tumours with these driving mutations are unclear and may be dependent on both tumour histological type and estrogen receptor (ERα) status [ 14- 17].
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