Sentence examples for mutations in core from inspiring English sources

Given the evidence for YAP/TAZ activation, there is a surprising lack of documented genetic mutations in core Hippo components in cancer [89].

In flies, mutations in core components of the Hippo signaling pathway, including the serine-threonine kinases Hippo and Warts lead to tissue overgrowth, in part by enhancing proliferation and inhibiting apoptosis.

Mouse embryos that have mutations in core non-canonical Wnt genes such as Vangl2 and Celsr1 have a shortened body axis and fail to initiate neural tube closure in the hindbrain and spinal region, although the neural tube in the forebrain is closed.

Mutations in core cohesin complex components have also been reported in individuals with CdLS-like phenotypes.

Other patients with CdLS that have reduced structural anomalies but significant intellectual disability harbor mutations in core components of the cohesin complex, such as SMC1A and SMC3.

Our results suggest that weakly deleterious mutations tend to be intergenic and nonsynonymous mutations, while highly deleterious mutations tend to be indels and mutations in core genes.

A similar rate of VHL mutations was observed when we assessed the mutational burden of each individual core, revealing mutations in 29/47 cores (62%).

Indeed, the patients with distinctive (and identical) mutations in the core gene sequence seem to produce anti-core antibodies directed to the less immunogenic, C-terminal part of the protein.

In addition, we used invariance of the core region since it was shown that mutations in the core region abolish or significantly reduce HH cleavage [ 59].

Importantly, many residues within the hydrophobic core are associated with drug resistance, and mutations in the core likely affect the dynamic properties of HIV PR and potentially affect the ability of PR to bind inhibitors and substrates.

Furthermore, comprehensive network analyses were performed to further mine the identified driver network properties: mutations in the core modules tended to mutate the hub genes that exhibited central regulatory roles.