Two patients had activating mutations in key signaling pathways (STAT5B (p.N642H) and CAMK2G (p.T306M)).
This effect can be alleviated by mutations in key amino acids of the U-binding pocket.
Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumour suppressor pathways.
Mutations in key regulatory genes of the Wnt β-catenin pathWnt β-catenincteristic of hepathwayiare tumours and promote their growth, dedifferentiation and dissemination.
Mutations in key conserved TOG2 determinants abrogate the ability of CLASP mutants to rescue bipolar spindle formation in Drosophila cells depleted of endogenous CLASP.
They are continuing her earlier work, studying how gene expression in worms changes as a result of mutations in key genes associated with aging, like the daf-2 gene.
Cancer, as well as other human disorders, has long been considered to result from the consequence of genetic mutations in key regulatory genes that reside in pathways controlling proliferation, cellular differentiation, DNA damage and repair.
Thymocytes with mutations in key signaling molecules in the phosphatidylinositol 3-kinase-Akt pathway manifest defects in survival, proliferation, and differentiation past the beta-selection checkpoint.
The color-coded list identifies documented mutations in key viral genes, along with literature citations and a description of how the mutation is believed to change biological function.
Like species, changes in languages can be tracked through the fate of certain words, just as mutations in key genes can tell a species' history.
Although the development of genetic diversity in cancer stem cells has not been well defined, SCS is now being used to study cancer stem cells to identify mutations in key functional pathways promoting tumorigenesis [31].
