Sentence examples for mutations in essential from inspiring English sources
Cancer cells often bypass growth checkpoints through genetic mutations in essential genes (Fig. 2).
Despite the presence of a variety of chromosomal aberrations, translocations, and mutations in essential growth and tumor suppressor genes in MM cells, oncogenomic studies have identified few differences distinguishing MGUS from MM.
Mutations in essential genes can result in lethality or a renal phenotype that is non-functioning.
Indeed, this organism is largely unique in being an animal model in which one can with relative ease identify rare conditional mutations in essential genes.
Modifications to the screening procedures that use egg-laying defective strains subsequently made it possible to isolate with relative ease thousands of conditional mutations in essential genes [25], [26], [27].
Our findings highlight the value of C. elegans for identifying useful temperature-sensitive mutations in essential genes, and provide new insights into the requirements for some of the affected loci.
More recently, the innovation of using of egg-laying defective strains made C. elegans a powerful system for isolating non-conditional mutation in essential genes required for embryogenesis [24].
"General" tag was assigned to genotypes involving at least one mutation in essential, general transcription factors (TAF1).
To further support genome-scale research in S. pombe, we generated a barcode-tagged fission yeast insertion mutant library that has the potential of generating viable mutations in both essential and non-essential genes and can be easily analyzed using standard molecular biological techniques.
The number of LT+ mutants also attests to the importance of the autophagy-lysosome pathway as a response to cellular damage or malfunction, since many of the LT+ mutations are in essential metabolic, biosynthetic, or quality control pathways.
Chaperones are also highly expressed and may buffer the deleterious effects of the large number of non-synonymous mutations observed in essential T. hominis genes.
